Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1382 | 1382-30430 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I47V, G48GMRV, I54V, V82A, L90M | L33F, F53FL, G73S | L10I, G16A, E34Q, R41K, D60E, I62V, L63P, A71V, V77I, I93L |
| >1382-30430| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVFQEMNLPGKWKPKIVVGIGGLVKVRQYEQVP IEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | T39E, E44D, D86DE, V118I, K122E, I135T, G196E, Q197E, R211K, V245EK |
| >1382-30430| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKRTQEFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEEHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |