Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1381 | 1381-30423 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, T12E, I13V, K14R, G16A, N37D, Q61D, L63P, I64V, T74A, V77I |
| >1381-30423| codons 4-99 TLWQRPIVEVRIAGQLKEALLDTGADDTVLEEMDLPGRWKPKMIVGIGGFTKVRQYDDIP VEICGHKAIGAVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219R | K103N | V108I, K238N | K43N, E44D, V118I, I142V, S162C, G196GE, E203K, R211K, K223Q, L228R, V245T |
| >1381-30423| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIKELRQHLWKWGFYTP DRKHQQEPPFRWMGYELHPDNWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |