<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1375 1375-30626 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215F A62V Y181C, G190A   R83RG, K122P, Q174R, I178L, V179I, G196E, Q197K, T200A, E203D, Q207E, R211K, L228H, V245M  
>1375-30626| codons 38-247
CTELEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLVDFRELNKGTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKRNPDLIICQYVDDLYVASDLEIEKHRAKIDELREHLWKWGFFTP
DKKHQKEPPFHWMGYELHPDKWTVQPIMLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, V82A, L90M V11I, L33I, K43IMT, F53L, L89V L10V, I13V, K14T, L19T, K20T, E35D, M36I, N37D, K55R, R57K, D60DN, Q61QR, I62V, L63P, I66IL, C67L, H69Q, A71I  
>1375-30626| codons 4-99
TLWQRPVITVTIGGQTTEALLDTGADDTIIEDIDLPGRWTPKIVGGIGGLLRVKQYNRVP
IELLGQKIIGTVLVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006