Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1374 | 1374-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, N88D | L10I, K20R, E35D, M36I, R41E, K55R, I62V, L63P, I64L, I66IV, H69R, A71T, I72E, Q92K, C95F |
| >1374-30623| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFEDINLPGEWKPKIIGGIGGFVRVRQYDQVP LEVCGRKTEGTVLVGPTPVNVIGRDLMTKIGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74V, Q151M, T215Y | D67H, K219Q | K103N, Y181C, G190A | V179FY | T69N, W88WC, K122P, R172RK, D177E, I202IV, R211K, F214FL, H221Y, E224ED |
| >1374-30623| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKHSNRWRKVVDFRELNKRTQDFCEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFKKQNPEIYICQYMDDLYVASDLEIGQHRTKVEELRQHLLKWGLYTP DQKYQKDPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |