Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2139 | 2139-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82VA, I84V, L90M | L33F, F53L, T74P | L5V, L10I, I13V, N37D, R41K, I62IV, L63P, A71V, I72IV, I93M |
| >2139-30818| codons 4-99 TVWQRPIVTVKIGGQLKEALLDTGADDTVFEEMDLPGKWKPKLIGGIGGLIKVRQYDQVP IEICGHKVVGPVLVGPTPANVIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | K103KN | K43N, V60VI, W88WC, V118I, K122E, I135T, S162Y, T200A, H208Y, R211K |
| >2139-30818| codons 38-247 CTELENEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |