Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2146 | 2146-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33F, G73S | L10I, K55KR, R57K, L63P, C67W, A71IV, Q92K, I93L |
| >2146-30708| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFMRVKQYDQIP IEIWGHKVISTVLVGPTPVNVIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N | K219Q | K103N | K122E, Q174R, I178L, D192H, G196E, T200I, Q207K, R211A, Q242H |
| >2146-30708| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDLVIYQYMDDLYVGSHLEIEQHRIKIEELRKHLLAWGFTTP DQKHQKEPPFLWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |