Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2145 | 2145-30707 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | A62V | K103N, Y188L | K49R, K102Q, K122E, L168*, I178L, H208Y, R211K, L228LH |
| >2145-30707| codons 38-247 CTELEKEGKISRIGPENPYNTPVFVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKI*EPFRKQNPDLVIYQYVDDLLVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L33F, G73S, L89V | L10I, I13IV, L19LI, E34EQ, D60E, I62V, L63P, A71V, V77I, I93L |
| >2145-30707| codons 4-99 TLWQRPIVTVKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFMKVRQYEQVP IEICGHKVISTVVIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |