Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1878 | 1878-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | F53FL, G73T, N83ND | L10I, I15IV, E34EAKT, L38W, P39Q, I62V, L63P, I64V, A71V, V77VI |
| >1878-30604| codons 4-99 TLWQRPIVTIKVGGQLKEALLDTGADDTILTEMNWQGRWKPKIVGGIGGLMKVRQYDQVP VEICGHKVITTVLIGPTPVDIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y181YDFV, Y188Y*FL | T39A, K43Q, K49KR, I50IV, S68G, V118I, K122E, I142IM, S162N, Q174QR, R211K | E53EK, L100L* |
| >1878-30604| codons 38-247 CAELEQEGKISRVGPKNPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AG*KKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGMRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKRNPDIVIVQYVDDLLVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |