Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1876 | 1876-30529 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E | L10IV, K20R, M36I, K55R, L63P, A71V, I72IT, Q92K, I93M |
| >1876-30529| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVREYDQIP IEICGHKVTGTVLVGPTPANIIGRNLMTKMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W | T215D | K103N | K43KN, V60I, V118I, D121H, K122E, D123E, I135T, D177DN, D192DN, G196E, E203EK, H208Y, R211K, K223Q |
| >1876-30529| codons 38-247 CTELENEGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLHEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPNIVIYQYVDDLYVGSNLEIEQHRTKIKELRQYLWKWGFDTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |