Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1875 | 1875-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y181C, G190A | K101H | K43E, E44A, V118I, K122E, D123DN, I142V, Q174L, N175Y, T200A, K201R, Q207E, R211K, L228H, V245T |
| >1875-30528| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKLYPDIVICQYVDDLYVASDLEIGQHRARIEELREHLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46*L, G48V, I54S, V82A | L10I, K14KR, N37D, L63P, K70KE, A71V, V77I, I93L |
| >1875-30528| codons 4-99 TLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIVGIGGFSKVRQYDQIP IEICGHEVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |