Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1695 | 1695-30429 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, I84V, L90M | L10F, Q58E, G73S, L89V | G16GA, K20I, M36I, I62V, L63P, A71V, Q92K |
| >1695-30429| codons 4-99 TLWQRPFVTIKIAGQLIEALLDTGADDTILEEINLPGRWKPKMVGGIGGFMKVREYDQVP IEICGHKVISTVLVGPTPVNVIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75T, M184V, L210W, T215Y | A62V, K219R | K101E, G190A | K43Q, V106I, V118I, K122E, I135T, Q207QK, R211K, F214L, K223Q, L228H, Q242K |
| >1695-30429| codons 38-247 CTELEQEGKISKIGPENPYNTPVFVIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHP AGLEKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIEELRKHLWKWGLYTP DRKHQQEPPFHWMGYELHPDKWTVKPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |