Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1630 | 1630-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, F53L, G73S | I15V, G16A, L19P, K20M, M36I, N37NS, R41K, L63P, A71V, I93L |
| >1630-30417| codons 4-99 TLWQRPFVTIKVAGQPMEALLDTGADDTVLEEISLPGKWKPKIIGGIGGLVKVRQYDQIP IEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K103N | K43E, V118I, K122E, I135T, Q174H, T200A, I202V, Q207E, R211K, E224ED, I244V, V245I | N57H |
| >1630-30417| codons 38-247 CTELEEEGKISKIGPENPYHTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKHNPDIVIYQYVDDLYVGSDLEIGQHRAKVEELREHLWKWGFYTP DKKHQKDPPFLWMGYELHPDKWTVQPVILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |