Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1624 | 1624-30324 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, K43T | L10I, I15V, K20I, E35D, M36I, K55KR, I62V, L63P, A71V, I72L, I85V, Q92K, C95L |
| >1624-30324| codons 4-99 TLWQRPIITIKVGGQLIEALLDTGADDTVLEDINLPGRWTPKLIGGIGGFVRVRQYDQVP IEICGHKVLGTVLVGPTPANIVGRNLMTKIGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | D67G, K219DN | K103KN | T39TS, E44D, I50IM, S68G, V118VI, K122E, I142IV, S162Y, G196GE, T200TA, E203EK, H208HY, V245T |
| >1624-30324| codons 38-247 CSELEKDGKISKMGPENPYNTPVFAIKKKGGTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIKELRQYLWRWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |