Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1619 | 1619-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | NNRTI|NRTI|PI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K103N | V108VI, K238KT | K43N, V60VI, A98S, K122KE, Q174QK, N175NY, I178IM, T200E, H221HY |
| >1619-30317| codons 38-247 CTELENEGKISKIGPENPYNTPIFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKYPDMVIYQYVDDLYVGSDLEIGQHREKIEELRQHLWRWGFYTP DKKYQKEPPFLWMGYELHPDTWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L10FV | I13V, R41H, F53I, D60E, L63P, I64V, K70R, A71V, V77VI, P79AS, I93L |
| >1619-30317| codons 4-99 TLWQRPVVTVKIGGQLKEALLDTGADDTVLEEMNLPGHWKPKIIGGIGGIIKVRQYEQIP VEICGHRVIGTVLIGSTPVNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |