Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1622 | 1622-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, V75M, M184V, T215Y | K103N | F227L | V60I, K82R, R83K, V90I, A98S, K122E, D123T, I135V, S162H, D177E, T200A, E203D, K223Q, L228R |
| >1622-30317| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKDSDRWRKLMDFRELNRKTQDFWEIQLGIPHP SGLKKNKSVTVLDVGDAYFSVPLDETFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQHSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRAKIDELRQHLLRWGFYTP DKKHQQEPPLRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10V, I13V, I15V, K20L, M36I, R41K, D60E, L63P, A71T |
| >1622-30317| codons 4-99 TLWQRPVVTVKVGGQLLEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFIKVRQYEQIP IEICGHKTIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |