Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1621 | 1621-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, L210W, T215Y | K103N | V108I | K43N, E44D, V118I, K122E, I142V, Q174K, N175Y, G196GE, T200A, E203D, Q207E, H208Y, R211K, L228H, Q242H |
| >1621-30317| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKYPDIVIYQYVDDLYVGSDLEIEQHRAKIDELREYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | V11I, F53FL, L89V | L10I, I13A, K20I, E35D, M36I, N37HQ, R57RK, Q61H, I62IV, L63P, A71V, I72E, T91TS, Q92K |
| >1621-30317| codons 4-99 TLWQRPIITAKIGGQLIEALLDTGADDTVLEDIQLPGRWKPKIVGGIGGLVKVKQYDHVP IEICGHKVEGTVLVGPTPVNVIGRNVMSKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |