Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1368 | 1368-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K219R | Y181C, G190A | V108I | K43M, K101Q, V118I, K122E, I135V, I142V, S162C, E194D, D218E, H221Y, L228R, V245Q |
| >1368-30630| codons 38-247 CTELEMEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYMDDLYVASDLDIGQHRTKIEELRQHLWRWGFYTP ERKYQKEPPFRWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, L33F, G73S | E34Q, K55R, R57K, I62V, L63P, C67W, A71T, I72T, V77I, P79D, I93L |
| >1368-30630| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFMRVKQYDQVP IEIWGHKTTSTVLIGDTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |