Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2491 | 2491-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, M184V, L210W, T215Y | K219R | K103NS, Y181C, G190A | K43Q, E44D, K101Q, V118I, D121H, K122E, E138EQ, I142V, R172K, D177E, G196E, E203K, H208Y, R211K, K223Q, L228R, V245K |
| >2491-30822| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKSKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSINNQTPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPEIVICQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP DRKHQQEPPFRWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, V11I, G73S | I15IV, A22V, E35D, M36I, R41K, D60E, I62V, L63P, A71V, I72L, N83S, I85V |
| >2491-30822| codons 4-99 TLWQRPFITIKVGGQLKEVLLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYEQVP IEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |