<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2491 2491-30822 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, M184V, L210W, T215Y K219R K103NS, Y181C, G190A   K43Q, E44D, K101Q, V118I, D121H, K122E, E138EQ, I142V, R172K, D177E, G196E, E203K, H208Y, R211K, K223Q, L228R, V245K  
>2491-30822| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLQKSKSVTVLDVGDAYFSIPLHEDFRKYTAFTIPSINNQTPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFKKQNPEIVICQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP
DRKHQQEPPFRWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, V11I, G73S I15IV, A22V, E35D, M36I, R41K, D60E, I62V, L63P, A71V, I72L, N83S, I85V  
>2491-30822| codons 4-99
TLWQRPFITIKVGGQLKEVLLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYEQVP
IEICGHKVLSTVLVGPTPVSVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006