Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1361 | 1361-30616 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103N, Y188L | T39A, K43E, E44D, K49R, E53D, A98S, V118I, K122E, D123DN, S162D, D177G, G196E, T200A, E203K, Q207E, H208HY, R211K, V245M | K223KPQT |
| >1361-30616| codons 38-247 CAELEEDGKISRIGPDNPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPGIVIYQYVDDLLVGSDLEIEQHRAKIKELREYLWKWGFYTP DKKHQTEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | V11I, L33F, G73T | L10I, I13V, L19I, E34Q, I62V, L63P, C67L, A71V, I72M, V77I |
| >1361-30616| codons 4-99 TLWQRPIITVKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGFVKVRQYDQVP IEILGHKVMTTVLIGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |