Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1362 | 1362-30616 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | K43N, E44D, K49R, V106I, V118I, K122E, S162D, I178M, Q197E, E203K, H208Y, R211K, K223E, L228R |
| >1362-30616| codons 38-247 CTELENDGKISRIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGEHRTKIKELRQYLWKWGFYTP DRKHQEEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, I84V, L90M | L10F, L33F, L89V | I13V, I15V, K20R, E35D, M36I, K43Q, R57K, D60E, L63P, A71V, P79A | R8Q |
| >1362-30616| codons 4-99 TLWQQPFVTVKVGGQLREALLDTGADDTIFEDINLPGRWQPKIVGGIGGFVKVKQYEQIP IEICGHKVIGTVLVGATPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |