Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1357 | 1357-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L33F | L10I, N37D, K55R, I62V, L63P, A71V, I72IT | F53FS |
| >1357-30625| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMDLPGRWKPKLIGGIGGSVRVRQYDQVP IEICGHKVTGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70G, L74I, V75T, L210W, T215F | K219W | Y181C, G190A | V108I | E79ED, K82KR, K122P, I167V, I178M, T200A, E203D, E204K, Q207E, R211K, L228H |
| >1357-30625| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTGWRKITDFRDLNRRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPDMVICQYMDDLYVASDLEIGQHRAKIDKLREHLWKWGFFTP DWKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |