Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1358 | 1358-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, L210W | T215C, K219R | K101E, Y181C, G190A | V108I | K43N, E44D, K49R, V118I, K122E, I135T, G196GV, R211K, F214L, K223Q, L228R, V245R |
| >1358-30625| codons 38-247 CTELENDGKISRIGPENPYNTPVFAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIVQHRTKIEELRQHLWKWGLCTP DRKHQQEPPFRWMGYELHPDKWTVQPIRLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54V, V82A | L33F, K43T | L10V, I13IV, L19I, L63LP, I64IV, T74S, V77I, L89LI, T91S |
| >1358-30625| codons 4-99 TLWQRPVVTVKIGGQIKEALLDTGADDTVFEEMNLPGRWTPKMIVGVGGFVKVRQYDQIP VEICGHKAIGSVLIGPTPANIIGRNILSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |