Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1356 | 1356-30530 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10F, L24I, L33F | I13V, L19I, K20T, M36L, K55KR, I62V, L63P, K70KR, A71V |
| >1356-30530| codons 4-99 TLWQRPFVTVKIGGQITEALIDTGADDTVFEELNLPGRWKPKLIGGIGGFVRVRQYDQVP IEICGHRVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | K43Q, E44D, K64KR, K103KR, V118I, K122E, S162C, R211K, D218E |
| >1356-30530| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKRKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |