Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1355 | 1355-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | V179D | T39A, K64H, T69N, K103R, E138Q, S162C, G196E, T200A, E203K, Q207E, R211I, V245K |
| >1355-30527| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIDIYQYMDDLYVGSDLEIEQHRAKIKELREHLLIWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | V11I, L24I, L33F, F53L, G73S | L10I, I13IV, I15V, G16E, M36ML, N37S, K55R, I62V, L63C, A71V |
| >1355-30527| codons 4-99 TLWQRPIITVKVEGQLKEALIDTGADDTVFEELSLPGRWKPKLIGGIGGLVRVRQYDQVC IEICGHKVISTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |