Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1353 | 1353-30711 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, Q151M | V75I, F77L, F116Y | G190A | V179D | S68G, V90I, K103R, V106L, V118I, I135L, E138Q, T165I, R172K, F214L |
| >1353-30711| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKRKDGTKWRKLIDLRELNKRTQDFWEIQLGIPHP AGLKKRKSLTVLDVGDAYYSIPLDKDFRKYTAFTIPSLNNQTPGIRYQYNVLPMGWKGSP AIFQSSMIKILEPFKKQNPDIDIYQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I, L33F, Q58E | L10I, I13V, L19I, L24M, M36ML, N37D, K55R, I62V, L63P, H69Y, A71T, I72T, V75I |
| >1353-30711| codons 4-99 TLWQRPIVTVKIGGQIKEAIMDTGADDTVFEELDLPGRWKPKLIGGIGGFVRVREYDQVP IEICGYKTTGTILVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |