Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1352 | 1352-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, V11I, Q58E, L89V | I13V, K20I, M36I, N37D, K55KR, I62V, L63P, H69Q, A71T, Q92K | T91CS |
| >1352-30519| codons 4-99 TLWQRPFITVKIGGQLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGFVRVREYDQVP IEICGQKTIGTVLVGPTPVNVIGRNVMSKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, M184V, L210W, T215Y | K103N | K238KT | S68G, D121H, K122E, R172RK, Q174K, D177E, I178L, R211RK, V245T |
| >1352-30519| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKKNPELVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDTWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |