Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1351 | 1351-30516 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70G, T215F | K219Q | Y188L | T39TA, V60I, K122E, I135T, I142L, K166R, G196GRS, H208Y, D218E, V245K |
| >1351-30516| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGLRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVIYQYMDDLLVGSDLEISQHRTKIEELRQYLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L10F, F53L | I13V, K14R, I15V, K20R, E35D, M36ML, N37T, R41K, I62V, L63P, H69K, A71V, V77I |
| >1351-30516| codons 4-99 TLWQRPFVTVRVGGQLREALLDTGADDTILEDLTLPGKWKPKIVGGIGGLLKVRQYDQVP IEICGKKVIGTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |