Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1923 | 1923-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L90M | L10V, I13V, L19I, K20I, R57K, D60E, L63P, A71T, V75VI, Q92QK |
| >1923-30708| codons 4-99 TLWQRPVVTVKIGGQIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFLKVKQYEQIP IEICGHKTIGTILVGPTPVNIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74LV, Y115YF, T215Y | L100LI, K103KN | K122E, T200A, L228LR |
| >1923-30708| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |