Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1280 | 1280-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11VI, L24LIM, Q58E, G73S | I15V, L19LP, K20V, A22V, D60N, I62IV, L63P, H69HQ, A71V, I72L, V77I, N83NS, I85V |
| >1280-30417| codons 4-99 TLWQRPFITIKVGGQPVEVLMDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYNQVP IEICGQKVLSTVLIGPTPVSVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, Y115F, M184MV, L210W, T215Y | K103N | P225PH | E44ED, V118VI, K122E, T200A, Q207K, R211A |
| >1280-30417| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRKHLWAWGFYTP DKKHQKEHPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |