Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1277 | 1277-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | K219R | K101E, Y181C, G190A | V108I | T39A, K43E, W88S, K102Q, D123E, I142V, V189I, Q197K, H221Y, L228R |
| >1277-30417| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFSEVQLGIPHP AGLEQKKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIGKHRTKIEELRQHLWRWGFYTP DRKYQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10V, E34Q, M36MI, N37S, I62V, L63T, H69Q, K70Q, A71V, I72T, Q92K, I93L |
| >1277-30417| codons 4-99 TLWQRPVVTIKIGGQLKEALLDTGADDTILQEISLPGRWKPKIVGGIGGFLKVRQYDQVT IEICGQQVTGTVLVGPTPVNVIGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |