Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2185 | 2185-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L10I, I15V, G16A, K20R, E35D, M36I, N37D, K55R, R57K, I62V, L63P, A71V, I93L |
| >2185-30822| codons 4-99 TLWQRPIVTIKVAGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVRVKQYDQVP IEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | E44D, V118I, I135T, K173E, Q174K, D177E, Q197E, I202V, Q207EK, H208Y, R211K, H221C, V245K | K43KHNQ |
| >2185-30822| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFREKNPEIVIYQYVDDLYVGSDLEIGEHRTKVEELRKYLWKWGFYTP DKKCQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |