Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2182 | 2182-40723 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82T, L90M | V11I, F53FL, G73S | L10I, I15V, Q18H, K20I, M36I, N37D, K55R, L63P, A71V, I72IM, I85V |
| >2182-40723| codons 1-99 PQITLWQRPIITIKVGGHLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGLVRVRQYD QIPIEICGHKVMSTVLVGPTPTNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74V, M184V, T215Y | K103N | T39TA, K122E, I135IT, I142T, E169D, V179VI, T200A, I202V, V245M, A272AP, A288S, R356K, R358K, A360AV, K366R, A371AV |
| >2182-40723| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIII YQYVDDLYVGSDLEIGQHRAKVEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGV HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |