Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1447 | 1447-30515 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, V82A, I84V, L90M | L10I, F53FY, I62IV, L63HP, I64IM, A71V, V77I, I93L |
| >1447-30515| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGYIKVRQYDQVP MEICGHKVIGTVLIGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, V75M, L210LW | F77L, T215DHLV | K101E, G190A | K43E, E44A, K82KR, R83K, V106VI, V118I, K122P, S163SC, I178L, V179VI, G196EK, Q207E |
| >1447-30515| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDLRELNRKTQDFWEVQLGIPHP AGLEKKKSITVLDVGDAYFSIPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSCMTKILEPFRKQNPDLIIYQYMDDLYVASDLEIKQHRTKIEELREHLWRWGFVTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |