Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1446 | 1446-30514 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MIL, I47IV, I54IMV, V82A, L90M | L33LF, K43T | L10I, L19I, K20R, E35D, M36I, L63P, I64V, I66IF, K70KR, A71V |
| >1446-30514| codons 4-99 TLWQRPIVTIKIGGQIREALLDTGADDTIFEDINLPGRWTPKLVGGIGGFVKVRQYDQIP VEFCGHRVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, L74V, M184V, T215Y | A62V | Y181C, G190S | K101H | K122E, D177E, T200TA, L228H | N57NH |
| >1446-30514| codons 38-247 CTEMEKEGKISKIGPENPYHTPVFVIKKKDSSKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |