Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1445 | 1445-30513 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L10F, V11VI, L33F, L89LV | I13V, K20T, E34EQ, E35DN, M36I, R41K, D60E, I62V, L63P, A71V, I72IM, P79H |
| >1445-30513| codons 4-99 TLWQRPFITVKIGGQLTEALLDTGADDTVFQNINLPGKWKPKMIGGIGGFLKVRQYEQVP IEICGHKVMGTVLVGHTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219D | K103N | L234I | K43E, K64R, V118I, K122KE, D123DE, G196E, T200A, E203K, Q207E, D218E, F227Y, L228H |
| >1445-30513| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIKELREHLWRWGFYTP EDKHQKEPPYHWMGYEIHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |