Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1348 | 1348-30509 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | Y188L | T39A, K43EQ, E44D, V60I, V118I, K122E, I135T, S162C, G196GE, T200TA, E203K, H208HY, R211K, K223E, L228R |
| >1348-30509| codons 38-247 CAELEQDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIEQHRAKIKELRQYLWKWGFYTP DNKHQEEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | G73T | L10I, E35D, N37S, K55KR, L63P, I64V, I66V, A71V, I93L |
| >1348-30509| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFLRVRQYDQIP VEVCGHKVITTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |