Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1347 | 1347-30505 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | V11I, L33LF, G73S, L89LV | L10I, I13V, I15IV, K20T, I62V, L63P, A71V, I72L, P79AS |
| >1347-30505| codons 4-99 TLWQRPIITVKVGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVLSTVLVGSTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115YF, M184V, L210W, T215Y | K219E | Y181C | K101KQ, K122E, S162C, E169D, Q174QR, Q197E, E203EK, Q207E, R211K, L228H |
| >1347-30505| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKRNPDIVICQYVDDLYVGSDLEIGEHRTKIKELREHLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |