<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1346 1346-30502 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I, L33LF L10I, E35ED, M36L, N37DE, L38W, P39PQ, I62V, L63P, A71V, I72IV  
>1346-30502| codons 4-99
TLWQRPIVTIKIGGQLKEALIDTGADDTVFEDLEWQGRWKPKLIGGIGGFVKVRQYDQVP
IEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y   K103NS A98AG T39D, E44D, V60I, V118I, K122E, I135T, S162C, D177DG, E194ED, G196E, E203K, Q207E, H208HY, R211K, K223KE, L228H, Q242H  
>1346-30502| codons 38-247
CDELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
GGLKKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLDIEQHRTKIKELREYLWKWGFYTP
DKKHQEEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006