Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1344 | 1344-30430 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48L, I54T, V82A, I84V, L90M | L33F, K43T, T74P | L10I, I13V, K20R, E34Q, E35D, M36I, N37S, R41K, I62V, L63P, I64V, A71T, I93L |
| >1344-30430| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFQDISLPGKWTPKMILGIGGFTKVRQYDQVP VEICGHKTIGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219W | Y181C | V179D | T39E, V60I, I135R, A158S, S162C, G196E, T200TA, Q207A, H208Y, R211K, D218E, L228H, V245K |
| >1344-30430| codons 38-247 CEELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP SIFQCSMTKILEPFRKQNPDIDICQYMDDLYVGSDLEIEQHRAKIEELRAYLLKWGFFTP EWKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |