Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1343 | 1343-30430 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | Y181C, G190A | A98G, K101H, V108VI | K43E, V118I, D123E, I135T, D177E, T200K, Q207DE, H208Y, R211K |
| >1343-30430| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLHKKKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRKKIEELREYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, G73T | L10I, I13V, L19Q, K20I, F53FY, K55KR, L63P, H69HR, A71V, I72IV |
| >1343-30430| codons 4-99 TLWQRPIVTVKIGGQQIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGYVRVREYDQIP IEICGRKVVTTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |