Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2348 | 2348-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | V11VI, G73S | L10I, I15V, G16GA, L19LI, E35D, N37H, R41K, K45R, L63P, A71V, I72L, C95L |
| >2348-30820| codons 4-99 TLWQRPIITIKVAGQIKEALLDTGADDTVLEDMHLPGKWKPRIIGGIGGFVKVRQYDQIP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGLTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219E | L100I, K103N | T39A, V60I, V90I, A98S, D121Y, K122E, I135T, S162Y, I202V, E203ED, V245K |
| >2348-30820| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHP SGIKKNKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVDELRQHLLRWGFFTP DEKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |