Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2176 | 2176-30627 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K219Q | Y181C, G190A | V108I | T39A, K43E, E44A, V60I, K101KQ, V118I, K122E, I142V, T200A, E203D, H208Y, R211RK, K223Q, L228H, Q242K, V245E |
| >2176-30627| codons 38-247 CAELEEAGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIDELRQYLWKWGFYTP DQKHQQEPPFHWMGYELHPDKWTVKPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76LV, V82VCFG, L90M | L33LFS, K43T, F53L, G73T, L89LV | L10I, G16GA, E34Q, M36MI, K55KR, I62V, L63P, A71I, V77VI, I93L |
| >2176-30627| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVSQEINLPGRWTPKIVGGIGGLMRVRQYDQVP IEICGHKIITTVVIGPTPGNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |