<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2176 2176-30627 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, L76LV, V82VCFG, L90M L33LFS, K43T, F53L, G73T, L89LV L10I, G16GA, E34Q, M36MI, K55KR, I62V, L63P, A71I, V77VI, I93L  
>2176-30627| codons 4-99
TLWQRPIVTIKIAGQLKEALLDTGADDTVSQEINLPGRWTPKIVGGIGGLMRVRQYDQVP
IEICGHKIITTVVIGPTPGNIIGRNVMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, K219Q Y181C, G190A V108I T39A, K43E, E44A, V60I, K101KQ, V118I, K122E, I142V, T200A, E203D, H208Y, R211RK, K223Q, L228H, Q242K, V245E  
>2176-30627| codons 38-247
CAELEEAGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIDELRQYLWKWGFYTP
DQKHQQEPPFHWMGYELHPDKWTVKPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006