Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1968 | 1968-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54IM, L76V, L90LM | G73S, L89LV | L10I, I13V, L19I, I62IV, L63P, A71V, V77I, I93L |
| >1968-30625| codons 4-99 TLWQRPIVTVKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFMKVRQYDQVP IEICGHKVISTVVIGPTPVNIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, M184V, L210W, T215Y | K219E | E44ED, V118VI, K122E, D123N, S162C, D177E, G196E, E203V, Q207E, H208Y, R211K, K223KT, L228H |
| >1968-30625| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRTKIVELREYLWKWGFYTP DEKHQTEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |