Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1340 | 1340-30421 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L33F, K43T, G73S, L89V | L10V, V11L, I13V, K14M, Q18H, E34Q, N37S, Q61H, I62V, L63P, A71I, V77I, V82VI, I93L | G94D |
| >1340-30421| codons 4-99 TLWQRPVLTVMIGGHLKEALLDTGADDTIFQEMSLPGRWTPKIVGGIGGFMKVRQYDHVP IEICGHKIISTVLIGPTPINIIGRNVMTQLDCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, L210W, T215Y | A62V, K219KR | K103N | V108I, V179E | E40F, K43E, K122E, S162C, D177E, I178M, V189I, H208Y, R211K, K223Q, L228R, V245T |
| >1340-30421| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFVIKKKDSDKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPEMEIYQYMDDLYIGSDLEIGQHRTKIEELRQYLWKWGFYTP DRKHQQEPPFRWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |