<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1340 1340-30421 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, L90M L33F, K43T, G73S, L89V L10V, V11L, I13V, K14M, Q18H, E34Q, N37S, Q61H, I62V, L63P, A71I, V77I, V82VI, I93L G94D
>1340-30421| codons 4-99
TLWQRPVLTVMIGGHLKEALLDTGADDTIFQEMSLPGRWTPKIVGGIGGFMKVRQYDHVP
IEICGHKIISTVLIGPTPINIIGRNVMTQLDCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, L210W, T215Y A62V, K219KR K103N V108I, V179E E40F, K43E, K122E, S162C, D177E, I178M, V189I, H208Y, R211K, K223Q, L228R, V245T  
>1340-30421| codons 38-247
CTFLEEEGKISKIGPENPYNTPVFVIKKKDSDKWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKQNPEMEIYQYMDDLYIGSDLEIGQHRTKIEELRQYLWKWGFYTP
DRKHQQEPPFRWMGYELHPDKWTVQPITLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006