Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1338 | 1338-30414 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | L10I, I13V, E35D, M36I, N37S, R41K, L63P, C67E, A71T |
| >1338-30414| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADNTVLEDISLPGKWKPKMIGGIGGFIKVRQYDQIP IEIEGHKTIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74LV, T215Y | K102Q, D121Y, K122E, D123E, I135IMV, I142V, S162W, K173KE, D177E, T200I, E203ED, R206RS, L228LR |
| >1338-30414| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKQKKSVTVLDVGDAYFSVPLYEEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSP AIFQWSMTKILEPFREQNPEIVIYQYMDDLYVGSDLEIGQHRIKIDELSQHLLRWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |