Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2211 | 2211-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, L90M | G73T, L89V | T4S, L10I, K20I, E35N, M36I, D60E, I62V, L63P, K70T, A71V, I72L | P44PL |
| >2211-30819| codons 4-99 SLWQRPIVTIKIGGQLIEALLDTGADDTVLENINLPGRWKLKIIGGVGGFVKVRQYEQVP IEICGHTVLTTVLVGPTPVNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184MV, L210W, T215Y | D67DG, K219N | Y181C | V108I, F227L | T39A, K43E, I50M, S68SG, A98S, K101Q, K102R, V118I, K122E, I135IL, E203K, Q207A, H208Y, R211K, K223E, L228R | L92V, G93R |
| >2211-30819| codons 38-247 CAELEEEGKISKMGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEVQVRIPHP SGLQRKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKIKELRAYLWKWGFYTP DNKHQEEPPLRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |