Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2197 | 2197-30703 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, V82A, I84V, L90M | L33F, Q58E, L89LV | L10V, I13V, K20MR, E35D, M36I, N37ND, I62IV, L63P, A71T, I72V, Q92QK, I93L |
| >2197-30703| codons 4-99 TLWQRPVVTVKIGGQLREALLDTGADDTVFEDIDLPGRWKPKLIGGIGGFVKVREYDQVP IEICGHKTVGTVLVGPTPANVIGRNVMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215Y | K219H | K103N | V108I | K49KR, V60I, K102R, K122E, D123N, I135T, T200A, L228H |
| >2197-30703| codons 38-247 CTELEKEGKISRIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRNKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFYTP DHKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |