Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2196 | 2196-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82S | L10V, I15V, G16GE, K20R, E35D, M36I, N37S, P39PS, R41K, R57K, I62V, L63C, A71V, I72V, T74S, V77I, I93L |
| >2196-30630| codons 4-99 TLWQRPVVTIKVEGQLREALLDTGADDTVLEDISLSGKWKPKIIVGIGGFTKVKQYDQVC IEICGHKVVGSVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, T215Y | T39TA, K43E, E44A, D123E, I135T, I167V, D177E, G196E, E204Q, W212L, D218E |
| >2196-30630| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRTKIEQLRQHLLRLGFYTP EKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |