Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2104 | 2104-30619 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82T | L33F | L10I, I13V, M36L, N37D, D60E, I62V, L63Q, I66F, H69Y, A71V, I72T |
| >2104-30619| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEELDLPGRWKPKMIVGIGGFTKVRQYEQVQ IEFCGYKVTGTVLVGPTPTNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, T215Y | K219N | Y181C | V179E | T39A, E40F, K43E, A98S, K102R, V111I, V118I, D123E, I135T, E204ED, H208Y, L210S, R211K, L228H |
| >2104-30619| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKRKKSVTVLDIGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIEICQYMDDLYVGSDLEIGQHRTKIEDLRQYLSKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |